This report looks at the developing digital library practices of leading universities and cultural institutions including Cornell University, Oregon State University, the University of Chicago and the Museum of Natural History, among others. In detailed profiles based on lengthy interviews with directors of digital resources and other individuals with authority over major digitization efforts, the study details developments in content management, marketing, metadata development, collaborations, revenue generation, copyright clearance, use of social media, grants and fundraising, program assessment and metrics, equipment use and acquisition, staff development, preservation, donor management and other areas of interest to digitizers of content in libraries, higher education, government and museums. The study looks closely at the emergence of the academic library as a publisher and generator of digital content, not just as a custodian or receptacle. Increasingly, digitizers of content have entered the scholarly and educational mainstream and have propelled their content into prominent positions in their institutions.